Regenerative Myo-Bionics Product Road Map

Bionically-Enhanced Muscle Transplant Constructs for Functional Muscle Remodeling

 

Multi-Factor Cell-Mediated MyoRegeneration System:-

Optimal Cell Delivery/Protection (MTCs, OCPs), AntiFibrosis (LIF), Neurotaxis (NGF), NMJ Formation (Ag/Lam)

Additive Biofabrication:- 3D Wet Spinning

Regenerative Myo-Bionics:-

High-Level Integration of Therapeutic Myoblasts into Muscle from Biosynthetic Fibres

Synthetic Patch Constructs for Soft Tissue   Repair & Replacement

From Muscular Dystrophy                                      to Muscle Patch for Trauma/Ablation,

Regenerative Sports Medicine &                          Age Related Tissue Degeneration

 

Cornock et al, Fiber Society Spring Technical Conference

Australia Proc, 2013:pp. 246-249). RIS ID 91658

Slide1.JPG
 
  1.  Stem Cells used to create MPC's

  2.  Genetic Correction of Cells

  3. Corrected Cells used as Therapeutic Myoblast Implant

Regenerative Myo-Bionics:-  Therapeutic Applications

High-Level Integration of Therapeutic Myoblasts into Muscle from Biosynthetic Fibres

Duchenne Muscular Dystrophy (DMD) & Facioscapulohumeral Muscular Dystrophy are devastating neuromuscular diseases & the two most common forms of known muscular dystrophy whilst Oncology Associated Cachexia plays a pivotal role in cancer survival & often determines if a patient is able to undergo chemotherapy or other treatment regimes.

Research to date has focused on experimental therapeutic approaches including exon skipping and screening for small molecules that repress undue Dux4 protein production or treatments to kill cancer cells.

 

These are important strategies but can be considered upstream with regard to the regeneration or replacement of muscle.

BioRegenex's approach can be considered downstream in that we are concerned with functional muscle remodeling &

the state of genetic muscle biology, the level of functionality a patient is left with once a candidate gene or protein responsible for disease pathology has been addressed. 

 

There is a consensus in the medical literature that neuromuscular disorders often lead to a pro fibrotic state and more broadly that many complications occur in neurological conditions due to denervation atrophy.

Therefore the degree of post disease tissue damage needs to be individually assessed and addressed in order to regain  functionality and ultimately a return to a pre-disease quality of life state.

BioRegenex's Regenerative Myo-Bionic Muscle Transplant Constructs (MTC's) are being developed to treat a range of neuromuscular & neurological disorders, using genetically corrected cells embedded in Biosynthetic Fibres, to introduce therapeutic myoblasts into muscle or repair damaged nerve.

The goal is to create a regenerative functional niche capable of resetting healthy tissue biology.

This enables a patient to grow new muscles or replace damaged nerve without the underlying genetic defect that leads to atrophy & disease pathology.

 
 

© 2019 BioRegenex Pty Ltd